Both mineralocorticoid (MRs) and glucocorticoid receptors (GRs) can mediate these effects. Addition of an extra MetS criterion point for AAs with hypertension eliminated the racial differences in PWV and CAIx but not RHI.Īlthough MetS is associated with microvascular dysfunction and increased arterial stiffness in both racial groups, AAs without MetS have greater vascular dysfunction compared with whites. DOI: 10.1210/en.2015-1390 Abstract Adrenal glucocorticoid hormones are potent modulators of brain function in the context of acute and chronic stress. However, in subjects without MetS, AAs had lower RHI (P <. As result of this my Fiat Panda was sold in February 2015 but on the 31st of October 2014 they charged me an AA memebership for 140£ while I was already with Halifaxt and their RAC service and on the 3rd of November 2015 they charged me another AA membership for 154£ while I was with Churchill and their Green Flag service (no need to say that. MetS was present in 24.0% of subjects and was associated with increased PWV (P <. Using applanation tonometry (Sphygmocor), central augmentation index (CAIx) and pulse wave velocity (PWV) were measured as indices of wave reflections and arterial stiffness, respectively. Using digital pulse amplitude tonometry, we estimated the reactive hyperemia index (RHI), a measure of microvascular endothelial function. We measured components of MetS in a community-based cohort of 951 AAs and white subjects (aged 48.8 ± 11 y, 47% AA, 55% female). The objective of the study was to evaluate the relationship between MetS and vascular function in a biracial cohort with the hypothesis that the diagnosis of MetS underestimates subclinical vascular disease in AAs.
African Americans (AAs) have high rates of cardiovascular disease and subclinical vascular disease including arterial stiffness and microvascular dysfunction but have relatively low rates of MetS. The diagnosis of metabolic syndrome (MetS) identifies individuals at risk for developing diabetes and cardiovascular disease.
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